Cytolysin-Mediated Translocation (CMT)

Cytolysin-Mediated Translocation (CMT) A Functional Equivalent of Type III Secretion in Gram-Positive Bacteria

Type III secretion for injection of effector proteins into host cells has not been described for Gram-positive bacteria despite their importance in disease. Here, we describe an injection pathway for the Gram-positive pathogen Streptococcus pyogenes that utilizes streptolysin O (SLO), a cholesterol-dependent cytolysin. The data support a model in which an effector is translocated through the SL...

Niacin‐mediated Tace activation ameliorates CMT neuropathies with focal hypermyelination

Charcot-Marie-Tooth (CMT) neuropathies are highly heterogeneous disorders caused by mutations in more than 70 genes, with no available treatment. Thus, it is difficult to envisage a single suitable treatment for all pathogenetic mechanisms. Axonal Neuregulin 1 (Nrg1) type III drives Schwann cell myelination and determines myelin thickness by ErbB2/B3-PI3K-Akt signaling pathway activation. Nrg1 ...

Charcot - Marie - Tooth disease ( CMT )

Diophantine Equations CMT : 2011 - 2012

Solution 1.1.1. The prime factorization of 720 is 2 · 3 · 5. If we look only at the prime factors of x, y, z, we see that the exponents of 2 in the factorizations of x, y, z must sum to 4, the exponents of 3 must sum to 2, and the exponents of 5 must sum to 0. The number of possible triples (a, b, c) that correspond to the exponents of 2 in the prime factorizations of x, y, z is simply the numb...

MT mediaLibTM for Chip MultiThreaded (CMT) Processors

Innovation in processor design tends to happen in waves. The introduction of the first 4-bit/8-bit microprocessor designs (the 4004/8008) by Intel in 1971/1972 triggered a wave of competing designs from other semiconductor companies, including Motorola, Zilog, MOS Technology, TI, Rockwell, RCA, Fairchild, and others. The SPARC® architecture was part of a wave of RISC processor designs that appe...